The following summary introduces three reports in 3 languages, PDF format titled “A Participatory Assessment on the Mental Health Status and Needs of Key Populations in 5 Countries in the Middle East and North Africa Region.” These reports provide valuable insights into the mental health challenges faced by key populations in the region. They offer a comprehensive assessment of the mental health status and specific needs of these populations, contributing to a better understanding of their experiences and informing targeted interventions and support. The reports highlight the urgent need for mental health services and advocate for inclusive and comprehensive approaches that address the unique mental health concerns of key populations in the Middle East and North Africa.